01 · Driver Mutations
The mutation that won't turn off
Normal
In lung cancer, the most important biomarkers are called driver mutations — genetic changes that lock a growth signal in the "on" position, telling cells to keep dividing long after they should stop.
That permanently-on signal is what makes these mutations so specific — and so targetable. Shutting it off is exactly what targeted drugs are designed to do.
Most non-small cell lung cancers have at least one driver mutation. NSCLC accounts for ~85% of all lung cancers.
Source: NCCN / NCI
Educational use only · Not a medical device
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